Discontinuation of Statin Therapy and Clinical Outcome
After Ischemic Stroke
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Status:
Completed. Results published October 2007.
Purpose:
To assess the impact of discontinued statin therapy on clinical outcome in patients discharged after an acute ischemic stroke.
Year Started:
2000
Year Finished:
2005
Design:
Prospective, observational study.
Inclusion Criteria
Discharge after acute ischemic stroke; absence of any major concurrent illness, including renal failure and malignancies; absence of any clinical and laboratory evidence of coronary heart disease (CHD) or of any other major cardiac affect or cardiac embolism; and discharge on statin therapy.
Patient Involvement:
Stroke severity on the index admission was assessed by the National Institutes of Health Stroke Scale (NIHSS). No patient received thrombolytic therapy during the index admission
Primary Outcome:
Mortality rate from any cause within 12 months of discharge.
Results:
Statin therapy discontinuation was found to be an independent predictor of all-cause 1-year mortality (p = 0.003), and 246 (38.9%) of the 631 patients discontinued statin therapy during the 12-month follow-up. Mortality rate was 116 (18%). Mortality was due to cardiovascular events in 93 cases (80%), from noncardiovascular events in 8 cases (6.l9%), and from unexplained causes in 15 cases (13%).
Source of Information:
Stroke. 2007;38:2652-2657.
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This information last updated on: 10/10/2007
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