Serum uric acid and brain ischemia in normal elderly adults
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Status:
Completed. Results published October 2007.
Purpose:
To determine if serum uric acid (UA) is related to hyperintense signals (pathological areas or mini strokes) in the cerebral white matter (WMH) of healthy adults.
Design:
Cross-sectional, observational study.
Exclusion Criteria
Patients who had a history of stroke, dementia, Parkinson disease, multiple sclerosis, renal failure, severe traumatic brain injury, or brain tumor, or who scored below 24 or 30 on the Mini-Mental State Examination.
Patient Involvement:
Participants underwent an assessment that included a physical and neurologic examination, psychiatric interview, laboratory blood studies, brain MRI scan, and neuropsychological testing on the same day. Participants underwent proton density and T2-weighted brain MRI scans.
Primary Outcome:
The association between serum UA and age (as advanced age is a strong predictor of large WMH volume).
Secondary Outcome:
Association between serum UA and sex, race, overweight (body mass index >/= 25 vs < 25) and presence vs absence of self-reported hypertension, diabetes, current tobacco use, or history of alcohol abuse or dependence.
Results:
Serum UA levels correlated with age (p = 0.008)and were higher for men than women (5.02 +/- 1.18 vs 4.00 +/- 1.38; p < 0.0001) and higher for overweight than normal weight subjects (4.79 +/- 1.32 vs 4.04 +/- 1.37; p < 0.0005). Serum UA levels did not differ by race (p = 0.395). The 59 individuals with hypertension had higher UA concentrations than those without (4.92 +/- 1.49 vs 4.26 +/- 1.28; p = 0.003). There were no significant differences between the patients with diabetes and those without, nor between those with or without tobacco use or alcohol abuse.
Source of Information:
Neurology 2007;69:1418–1423.
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This information last updated on: 10/5/2007
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